학술논문
Identification of a human helper T cell population that has abundant production of interleukin 22 and is distinct from [T.sub.H]-17, [T.sub.H]1 and [T.sub.H]2 cells
Document Type
Report
Source
Nature Immunology. August 2009, Vol. 10 Issue 8, p864, 9 p.
Subject
Language
English
ISSN
1529-2908
Abstract
Interleukin 22 (IL-22), a member of the IL-10 (AO01243) family (1-3), is important in regulating inflammatory responses associated with many autoimmune diseases. The receptor for IL-22 is a complex of [...]
Interleukin 22 (IL-22) is a member of the IL-10 cytokine family that is involved in inflammatory and wound healing processes. Originally considered a T helper type 1 ([T.sub.H]1)-associated cytokine, IL-22 has since been shown to be produced mainly by IL-17-producing helper T cells ([T.sub.H]-17 cells). Here we describe a previously uncharacterized IL-22-producing human helper T cell population that coexpressed the chemokine receptor CCR6 and the skin-homing receptors CCR4 and CCR10. These cells were distinct from both [T.sub.H]-17 cells and TO cells. Downregulation of either the aryl hydrocarbon receptor (AHR) or the transcription factor RORC by RNA-mediated interference affected IL-22 production, whereas IL-17 production was affected only by downregulation of RORC by RNA-mediated interference. AHR agonists substantially altered the balance of IL-22- versus IL-17-producing cells. This subset of IL-22-producing cells may be important in skin homeostasis and pathology.
Interleukin 22 (IL-22) is a member of the IL-10 cytokine family that is involved in inflammatory and wound healing processes. Originally considered a T helper type 1 ([T.sub.H]1)-associated cytokine, IL-22 has since been shown to be produced mainly by IL-17-producing helper T cells ([T.sub.H]-17 cells). Here we describe a previously uncharacterized IL-22-producing human helper T cell population that coexpressed the chemokine receptor CCR6 and the skin-homing receptors CCR4 and CCR10. These cells were distinct from both [T.sub.H]-17 cells and TO cells. Downregulation of either the aryl hydrocarbon receptor (AHR) or the transcription factor RORC by RNA-mediated interference affected IL-22 production, whereas IL-17 production was affected only by downregulation of RORC by RNA-mediated interference. AHR agonists substantially altered the balance of IL-22- versus IL-17-producing cells. This subset of IL-22-producing cells may be important in skin homeostasis and pathology.