학술논문
Glycophanes, cyclodextrin-cyclophane hybrid receptors for apolar binding in aqueous solutions: a stereoselective carbohydrate-carbohydrate interaction in water
Document Type
Academic Journal
Source
Journal of the American Chemical Society. Nov 3, 1993, Vol. 115 Issue 22, p10066, 11 p. chart
Subject
Language
ISSN
0002-7863
Abstract
Alpha,alpha'-trehalose and 2,7-dihydroxynapthalene or 4,4'-isopropylidenediphenol serve as sources for the synthesis of a new class of neutral chiral receptors, glycophanes. These receptors are endowed with a cyclodextrin-cyclophane hybrid nature. Cyclodextrins are cyclic oligosaccharides comprising alpha-D-glucopyranose and have a characteristic chiral nature and a lipophilic site. Glycophanes and oligosaccharides exhibit a stereoselective carbohydrate-carbohydrate interaction in water. Glycophane receptors possess amphiphilic features characterized by the presence of a polar carbohydrate region in the vicinity of an apolar surface. This feature of glycophane confers it with the potential to simulate interactions between carbohydrates and their conventional receptors.