학술논문
PREVALENCE AND ASSOCIATED FACTORS OF ADVERSE EFFECTS IN CHILDREN AND ADOLESCENTS TREATED WITH SELECTIVE SEROTONIN REUPTAKE INHIBITORS: A CHART REVIEW STUDY/SECICI SEROTONIN GERI ALIM INHIBITORLERIYLE TEDAVI EDILEN COCUK VE ERGENLERDE YAN ETKILERIN SIKLIGI VE ILISKILI FAKTORLER: BIR DOSYA TARAMA CALISMASI
RESEARCH/ARASTIRMA
RESEARCH/ARASTIRMA
Document Type
Report
Source
Journal of Istanbul Faculty of Medicine. March 2023, Vol. 86 Issue 1, p28, 9 p.
Subject
Language
English
ISSN
1305-6433
Abstract
INTRODUCTION Selective serotonin reuptake inhibitor (SSRI) drugs have been widely used among the young population to treat psychiatric disorders with or without FDA-approved indications (1, 2). In clinical practice, major [...]
Objective: This study aims to examine the prevalence and associated clinical and sociodemographic factors of adverse effects in medication among naive young subjects who received selective serotonin reuptake inhibitor (SSRI) monotherapy. Material and Methods: The medical records of 85 patients who had received SSRI monotherapy in a university hospital's child and adolescent psychiatry clinic were reviewed. The subjects who met the inclusion criteria were included in the study. Results: A total of 67 subjects (10.82[+ or -]3.63 years) were included. More than half (n=39, 58.9%) developed at least one adverse effect possibly associated with SSRI treatment, with psychic (n=25, 37.3%) and autonomic (n=20, 29.9%) adverse effects as well as behavioral activation (n=13, 19.4%) being the most frequently reported. Medication was discontinued in 13 subjects (19.4%) due to adverse effects, with behavioral activation (6 out of 13 subjects) being the most frequent reason for discontinuation. The development of behavioral activation was significantly associated with younger age, diagnosis of obsessive compulsive disorder in the subjects, and psychiatric history in the subjects' fathers (p value Conclusions: Despite the fact that SSRIs are generally safe and well-tolerated in young subjects, adverse effects may be frequent, and medication discontinuation may be required under some conditions. Thus, clinicians treating young subjects should be cautious, particularly about the development of behavioral activation. They should also be mindful of the clinical and sociodemographic factors associated with the adverse effects that may arise during SSRI treatment. Keywords: Adolescents, Adverse Effects, Children, Side Effects, Selective Serotonin Reuptake Inhibitors, Behavioral Activation Amac: Bu calisma, secici serotonin geri alim inhibitoru (SSRI) monoterapisi alan genc hastalar arasinda ilac yan etki sikligini ve bu yan etkilerle iliskili klinik ve sosyodemografik faktorleri incelemeyi amaclamaktadir. Gerec ve Yontem: Bir universite hastanesinin cocuk ve ergen psikiyatrisi kliniklerinde SSRI monoterapisi alan 85 hastanin tibbi kayitlari incelendi. Dahil edilme kriterlerini karsilayan hastalar calismaya dahil edildi. Bulgular: Toplam 67 hasta (10,823,63 yil) dahil edildi. Hastalarin yarisindan fazlasi (n=39, %58,9) muhtemelen SSRI tedavisi ile iliskili en az bir yan etki gelistirdi. En sik bildirilen yan etkiler; psisik (n=25, %37,3) ve otonomik yan etkilerin (n=20, %29,9) yanisira davranissal aktivasyondu (n=13, %19,4). Yan etkiler nedeniyle 13 hastada (%19,4) ilac tedavisi sonlandirildi ve en sik ilac kesme nedeni davranissal aktivasyondu (13 hastanin 6'si). Davranis aktivasyonunun ortaya cikmasi; daha kucuk yas, hastada obsesif kompulsif bozukluk tanisi varligi ve babada psikiyatrik hastalik varligi ile anlamli olarak iliskiliydi (p degeri Sonuc: SSRI'lar genc hastalarda genellikle guvenli ve iyi tolere edilmesine ragmen, yan etkiler sik olabilir ve bazi durumlarda ilacin kesilmesi gerekebilir. Bu nedenle, genc hastalari tedavi eden klinisyenler, ozellikle davranissal aktivasyonun gelisimi konusun- da dikkatli olmalidir. Ayrica SSRI tedavisi sirasinda ortaya cikabilecek yan etkilerle iliskili klinik ve sosyodemografik faktorleri de dikkate almalidirlar. Anahtar Kelimeler: Ergen, Yan Etki, Cocuk, Secici Seratonin Geri Alim Inhibitoru, Davranissal Aktivasyon
Objective: This study aims to examine the prevalence and associated clinical and sociodemographic factors of adverse effects in medication among naive young subjects who received selective serotonin reuptake inhibitor (SSRI) monotherapy. Material and Methods: The medical records of 85 patients who had received SSRI monotherapy in a university hospital's child and adolescent psychiatry clinic were reviewed. The subjects who met the inclusion criteria were included in the study. Results: A total of 67 subjects (10.82[+ or -]3.63 years) were included. More than half (n=39, 58.9%) developed at least one adverse effect possibly associated with SSRI treatment, with psychic (n=25, 37.3%) and autonomic (n=20, 29.9%) adverse effects as well as behavioral activation (n=13, 19.4%) being the most frequently reported. Medication was discontinued in 13 subjects (19.4%) due to adverse effects, with behavioral activation (6 out of 13 subjects) being the most frequent reason for discontinuation. The development of behavioral activation was significantly associated with younger age, diagnosis of obsessive compulsive disorder in the subjects, and psychiatric history in the subjects' fathers (p value Conclusions: Despite the fact that SSRIs are generally safe and well-tolerated in young subjects, adverse effects may be frequent, and medication discontinuation may be required under some conditions. Thus, clinicians treating young subjects should be cautious, particularly about the development of behavioral activation. They should also be mindful of the clinical and sociodemographic factors associated with the adverse effects that may arise during SSRI treatment. Keywords: Adolescents, Adverse Effects, Children, Side Effects, Selective Serotonin Reuptake Inhibitors, Behavioral Activation Amac: Bu calisma, secici serotonin geri alim inhibitoru (SSRI) monoterapisi alan genc hastalar arasinda ilac yan etki sikligini ve bu yan etkilerle iliskili klinik ve sosyodemografik faktorleri incelemeyi amaclamaktadir. Gerec ve Yontem: Bir universite hastanesinin cocuk ve ergen psikiyatrisi kliniklerinde SSRI monoterapisi alan 85 hastanin tibbi kayitlari incelendi. Dahil edilme kriterlerini karsilayan hastalar calismaya dahil edildi. Bulgular: Toplam 67 hasta (10,823,63 yil) dahil edildi. Hastalarin yarisindan fazlasi (n=39, %58,9) muhtemelen SSRI tedavisi ile iliskili en az bir yan etki gelistirdi. En sik bildirilen yan etkiler; psisik (n=25, %37,3) ve otonomik yan etkilerin (n=20, %29,9) yanisira davranissal aktivasyondu (n=13, %19,4). Yan etkiler nedeniyle 13 hastada (%19,4) ilac tedavisi sonlandirildi ve en sik ilac kesme nedeni davranissal aktivasyondu (13 hastanin 6'si). Davranis aktivasyonunun ortaya cikmasi; daha kucuk yas, hastada obsesif kompulsif bozukluk tanisi varligi ve babada psikiyatrik hastalik varligi ile anlamli olarak iliskiliydi (p degeri Sonuc: SSRI'lar genc hastalarda genellikle guvenli ve iyi tolere edilmesine ragmen, yan etkiler sik olabilir ve bazi durumlarda ilacin kesilmesi gerekebilir. Bu nedenle, genc hastalari tedavi eden klinisyenler, ozellikle davranissal aktivasyonun gelisimi konusun- da dikkatli olmalidir. Ayrica SSRI tedavisi sirasinda ortaya cikabilecek yan etkilerle iliskili klinik ve sosyodemografik faktorleri de dikkate almalidirlar. Anahtar Kelimeler: Ergen, Yan Etki, Cocuk, Secici Seratonin Geri Alim Inhibitoru, Davranissal Aktivasyon