학술논문
Autocrine tumor necrosis factor (TNF) and lymphotoxin (LT) alpha differentially modulate cellular sensitivity to TNF/LT-alpha cytotoxicity in L929 cells
Document Type
Academic Journal
Source
The Journal of Cell Biology. Dec 28, 1998, Vol. 143 Issue 7, p2057, 9 p.
Subject
Language
ISSN
0021-9525
Abstract
Research was conducted to examine the hypothesis that autocrine tumor necrosis factor (TNF) and lymphotoxin (LT) alpha differentially modulate cellular sensitivity to TNF/LT-alpha cytotoxicity in L929 cells. Detailed investigation of the biological activities of autocrine LT-alpha production was performed using several types of TNF-resistant L929 cell derivatives. Results indicate that the membrane retention of newly synthesized TNF or LT-alpha is critical for receptor downmodulation and TNF/LT-alpha resistance.