부산대학교 도서관

People infected with human immunodeficiency virus type 1 (HIV-1) but show no apparent progression of the disease appear to have a relatively low viral load and their lymph nodes and immune functions appear to remain effective. A percentage of people infected with HIV-1 show no progression of the disease for years. A study compared 15 of these patients, who had been infected at least 7 years, with 18 patients with progressive HIV disease. The lymph nodes of the non-progressive patients did not show the large germinal centers, follicle lysis, hyperplasia and lymphocyte depletion found in the nodes of the progressive patients. HIV-1 levels in plasma and peripheral-blood mononuclear cell were significantly lower for the non-progressive patients, who also had higher tithers of neutralizing antibodies than were found in the progressive subjects. Replication of the virus was found in the lymph nodes of the non-progressive patients, however.