부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.archoralbio.2008.05.005 Byline: Shuo Chen (a), Lei Chen (a), Allen Jahangiri (a), Bo Chen (a), Yimin Wu (b), Hui-Hsiu Chuang (c), Chunlin Qin (d), Mary MacDougall (e) Keywords: SIBLING; Odontoblasts; Dentinogenesis; Dentin; Teeth Abstract: Small integrin-binding ligand N-linked glycoproteins (SIBLINGs) are expressed in dentin and believed to control dentinogenesis. Five members of SIBLING family include bone sialoprotein (BSP), osteopontin (OPN), matrix extracellular phosphoglycoprotein (MEPE), dentin matrix protein 1 (DMP1) and dentin sialophosphoprotein (DSPP). These genes are clustered on chromosome 4q in humans and share similar biological features. DSPP and DMP1 are processed into given structural/functional fragments in rat and porcine. It still remains unclear whether these evidences occur in mouse and other SIBLING members are also processed into given fragments from their parent precursors. The aim of this study was to identify expression and processing of the five proteins in two mouse odontoblastic cell lines. Author Affiliation: (a) Department of Pediatric Dentistry, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229-3900, USA (b) Department of Neurosurgery, The University of Texas Health Science Center at San Antonio, TX, USA (c) Department of Orthodontics, The University of Texas Health Science Center at San Antonio, TX, USA (d) Department of Biomedical Sciences, Baylor College of Dentistry, Dallas, TX, USA (e) Department of Oral/Maxillofacial Surgery, University of Alabama at Birmingham School of Dentistry, Birmingham, AL, USA Article History: Accepted 6 May 2008