학술논문
Nitric Oxide Donors Selectively Reduce the Expression of Matrix Metalloproteinases-8 and -9 by Human Diabetic Skin Fibroblasts
Document Type
Author abstract
Author
Source
Journal of Surgical Research. June 1, 2007, Vol. 140 Issue 1, p90, 9 p.
Subject
Language
English
ISSN
0022-4804
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.jss.2006.11.010 Byline: Jamey W. Burrow ([cor]), Joey A. Koch ([cor]), Hui-Hsiu Chuang ([cor]), Weinan Zhong ([cor]), David D. Dean ([cor]), Victor L. Sylvia ([cor]) Keywords: nitric oxide; matrix metalloproteinase; fibroblast; diabetes; wound healing Abstract: Chronic, nonhealing skin wounds are a common ailment in uncontrolled diabetes and are associated with significant morbidity. The nonhealing diabetic foot wound displays pathologically elevated matrix metalloproteinase (MMP) activity. In contrast, the concentration of nitric oxide (NO) is significantly reduced in these chronic ulcers. Addition of NO to diabetic wounds improves wound healing, but the mechanism for this effect is poorly understood. Author Affiliation: ([cor]) Department of Orthopaedics, University of Texas Health Science Center at San Antonio, San Antonio, Texas (a ) Department of Biomedical Engineering, University of Texas at San Antonio, San Antonio, Texas Article History: Received 10 August 2006