부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.tet.2005.06.086 Byline: Kennett SprogA[cedilla]e (a), SA[cedilla]ren Manniche (a), Thomas Ostenfeld Larsen (b), Carsten Christophersen (c) Abstract: Two compounds janoxepin (1) and brevicompanine B (2) were isolated from the fungus Aspergillus janus and the structures elucidated by one- and two-dimensional NMR spectroscopic methods and mass spectrometry. Janoxepin is a novel oxepin derivative with a rare d-leucine incorporated. Brevicompanine B has previously only been isolated from Penicillium brevicompactum. Both compounds were tested in antimicrobial assays and found to be active against the malaria parasite Plasmodium falciparum 3D7 (IC.sub.50-values of 28 and 35mg/ml, respectively). However, no activity was observed in antifungal or antibacterial assays. Author Affiliation: (a) Department of Medicinal Chemistry, The Danish University of Pharmaceutical Sciences, Universitetsparken 2, DK-2100 Copenhagen, Denmark (b) Mycology Group, Department of Biotechnology and Department of Organic Chemistry, Technical University of Denmark, DK-2800 Lyngby, Denmark (c) Marine Chemistry Section, Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark Article History: Received 21 April 2005; Revised 8 June 2005; Accepted 23 June 2005