학술논문
Rat brain expresses an alternatively spliced form of the dihydropyridine-sensitive L-type calcium channel alpha-2 subunit
Document Type
Academic Journal
Author
Source
Proceedings of the National Academy of Sciences of the United States. April 15, 1992, Vol. 89 Issue 8, p3251, 5 p.
Subject
Language
ISSN
0027-8424
Abstract
The cDNA coding for the 1, 4-dihydropyridine-sensitive calcium channel alpha-2 subunit was isolated from a rat hippocampus cDNA library. Sequence analysis showed that the clone codes for a protein of 1,091 amino acids and has a 95% identity with the alpha-2 subunit of the rabbit skeletal muscle. The major difference between these two proteins lies in an insertion and a deletion in the region between the transmembrane domains 1 and 2. The high degree of homology and distribution of these alpha-2 variants suggest that they are transcribed from a single gene, but differ by alternative spicing of the primary transcript.