학술논문

The genome of the natural genetic engineer agrobacterium tumefaciens C58. (Research Articles)
Document Type
Academic Journal
Source
Science. December 14, 2001, Vol. 294 Issue 5550, p2317, 7 p.
Subject
United States
Language
English
ISSN
0036-8075
Abstract
The 5.67-megabase genome of the plant pathogen Agrobacterium tumefaciens C58 consists of a circular chromosome, a linear chromosome, and two plasmids. Extensive orthology and nucleotide colinearity between the genomes of A. tumefaciens and the plant symbiont Sinorhizobium meliloti suggest a recent evolutionary divergence. Their similarities include metabolic, transport, and regulatory systems that promote survival in the highly competitive rhizosphere; differences are apparent in their genome structure and virulence gene complement. Availability of the A. tumefaciens sequence will facilitate investigations into the molecular basis of pathogenesis and the evolutionary divergence of pathogenic and symbiotic lifestyles.
Agrobacterium tumefaciens is an α-proteobacterium of the family Rhizobiaceae and a member of the diverse Agrobacterium genus. A ubiquitous soil organism and etiological agent of the plant disease crown gall [...]