학술논문
Selective action of 4'-Azidothymidine triphosphate on reverse transcriptase of human immunodeficiency virus type 1 and human DNA polymerases alpha and beta
Document Type
Academic Journal
Author
Source
Biochemistry. June 15, 1993, Vol. 32 Issue 23, p6002, 9 p. graph
Subject
Language
ISSN
0006-2960
Abstract
A study explored the manner in which 4'-Azidothymidine (ADRT) limits human immunodeficiency virus (HIV) reverse transcriptase (HIV-RT) as ADRT 5'-tripohsphate (ADRT-TP), the active intracellular metabolite of ADRT, and as the ADRT-MP molecule incorporated into DNA. It compared their effects on human DNA polymerases alpha and beta. The inhibition is more powerful against RNA to DNA synthesis than it is with DNA to DNA synthesis.