학술논문

Perivascular macrophages mediate neutrophil recruitment during bacterial skin infection
Document Type
Report
Source
Nature Immunology. January 1, 2014, Vol. 15 Issue 1, p45, 12 p.
Subject
Physiological aspects
Research
Properties
Bacterial infections -- Physiological aspects
Macrophages -- Properties
Skin diseases -- Physiological aspects
Physiological research
Immune response -- Research
Language
English
ISSN
1529-2908
Abstract
Neutrophils, through their ability to be rapidly recruited to tissues and deploy a diverse array of antimicrobial effector mechanisms, are essential for the clearance of many bacterial pathogens (1). Given [...]
Transendothelial migration of neutrophils in postcapillary venules is a key event in the inflammatory response against pathogens and tissue damage. The precise regulation of this process is incompletely understood. We report that perivascular macrophages are critical for neutrophil migration into skin infected with the pathogen Staphylococcus aureus. Using multiphoton intravital microscopy we showed that neutrophils extravasate from inflamed dermal venules in close proximity to perivascular macrophages, which are a major source of neutrophil chemoattractants. The virulence factor a-hemolysin produced by S. aureus lyses perivascular macrophages, which leads to decreased neutrophil transmigration. Our data illustrate a previously unrecognized role for perivascular macrophages in neutrophil recruitment to inflamed skin and indicate that S. aureus uses hemolysin- dependent killing of these cells as an immune evasion strategy.