부산대학교 도서관

To purchase or authenticate to the full-text of this article, please visit this link: http://dx.doi.org/10.1111/j.1524-4725.2007.33115.x Byline: ALASTAIR CARRUTHERS (*), MELISSA BOGLE ([dagger]), JEAN D. A. CARRUTHERS ([double dagger]), JEFFREY S. DOVER (s.[parallel]), KENNETH A. ARNDT (s.[parallel][paragraph]), TE-SHAO HSU (s.[parallel]), JUDE POIRIER (**) Abstract: BACKGROUND There has been considerable discussion about the effect of the degree of dilution of botulinum toxin (BTX) but very few scientific studies. OBJECTIVE The objective was to observe as to whether a fivefold difference in concentration of BTX solution would produce a difference in clinical effect or duration of effect. METHODS AND MATERIALS Twenty individuals were enrolled at two sites and a within-subject paired-comparison study was performed on the lateral orbital area with a single injection of 5 U of BTX (BOTOX Cosmetic, Allergan Inc., Irvine, CA). The results were assessed both clinically and using a computer-assisted estimation of the degree of wrinkling. RESULTS No statistically significant differences were observed between the two sides. CONCLUSIONS This is a small study and it may be that dilution does affect BTX result. We were, however, unable to detect any difference in this study, which suggests that the degree of dilution, at least within a fivefold margin, has only a small effect on the results of BTX injection in the lateral orbital area. Author Affiliation: (*)Department of Dermatology ([double dagger])Department of Ophthalmology; University of British Columbia, Vancouver, British Columbia, Canada ([dagger])Laser and Cosmetic Surgery Center of Houston, Texas (s.)Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut ([parallel])Department of Medicine (Dermatology), Dartmouth Medical School, Hanover, New Hampshire ([paragraph])Department of Dermatology, Harvard Medical School, Boston, Massachusetts (**)Carruthers Clinical Research, Vancouver, British Columbia, Canada Article note: Address correspondence and reprint requests to: Alastair Carruthers, MD, 943 West Broadway, Suite 820, Vancouver, BC V5Z 4E1, Canada, or e-mail: alastair@carruthers.net.