학술논문
No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population
Document Type
Academic Journal
Author
Dumitrescu, Logan; Carty, Cara L.; Franceschini, Nora; Hindorff, Lucia A.; Cole, Shelley A.; Buzkova, Petra; Schumacher, Fredrick R.; Eaton, Charles B.; Goodloe, Robert J.; Duggan, David J.; Haessler, Jeff; Cochran, Barbara; Henderson, Brian E.; Cheng, Iona; Johnson, Karen C.; Carlson, Chris S.; Love, Shelly-Anne; Brown- Gentry, Kristin; Nato, Alejandro Q.; Quibrera, Miguel; Shohet, Ralph V.; Ambite, Jose Luis; Wilkens, Lynne R.; Marchand, Loic Le; Haiman, Christopher A.; Buyske, Steven; Kooperberg, Charles; North, Kari E.; Fornage, Myriam; Crawford, Dana C.
Source
Human Genetics. December 1, 2013, Vol. 132 Issue 12, p1427, 5 p.
Subject
Language
English
ISSN
0340-6717
Abstract
Short report Candidate gene and genome-wide association studies (GWAS) have identified numerous common variants associated with high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), and triglycerides (TG). However, examination of [...]
Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP x smoking interactions.
Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP x smoking interactions.