학술논문
Effects of Moderate Exercise Training on ApoE and ApoCIII in Metabolic Syndrome
Original Research
Original Research
Document Type
Report
Source
European Journal of Therapeutics. March 2023, Vol. 29 Issue 1, p65, 9 p.
Subject
Language
English
ISSN
2564-7784
Abstract
INTRODUCTION Many adipokines and cytokines with paracrine, endocrine and neural effects are synthesized, and released in adipose tissue. It has been reported that adipose tissue has important roles in inflammation, [...]
Objective: Metabolic syndrome (MetS) is an endocrinopathy with a combination of cardiovascular and metabolic compounds. In our study, it is expected to obtain results showing that mortality rate, loss of workforce, and treatment costs due to disorders caused by MetS can be reduced by physical exercise. The study analyses the effect of moderate exercise training on this Apolipoprotein E (ApoE), Apolipoprotein Clll (ApoCIII), adiponectin, resistin, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-a) which are thought to have a role in the deterioration of glucose and lipid metabolism in MetS. Methods: This clinical experimental study consists of 3 groups. The MetS+E (n=24) group, which included the participants who agreed to participate in the exercise program in addition to their medical treatment, the MetS (n=23) group who received medical treatment but did not exercise, and the Control+E (n=25) group, which included healthy volunteers who had the same protocol as MetS+E. ApoE, ApoCIII, adiponectin, resistin, IL-6, and TNF-a plasma levels of all participants were measured both at the beginning of the study and at the end of the protocol. Results: At the end of the study we reached the following findings; insulin and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) levels decreased in exercise groups (p=0,03). ApoCIII levels are increased all the groups after the study (p Conclusion:Training showed metabolic, anti-inflammatory and physical improvements independent of ApoE and ApoCIII in those with MetS. Keywords: Adipokines, Apolioprotein Clll, Apolipoprotein E, exercise, metabolic syndrome.
Objective: Metabolic syndrome (MetS) is an endocrinopathy with a combination of cardiovascular and metabolic compounds. In our study, it is expected to obtain results showing that mortality rate, loss of workforce, and treatment costs due to disorders caused by MetS can be reduced by physical exercise. The study analyses the effect of moderate exercise training on this Apolipoprotein E (ApoE), Apolipoprotein Clll (ApoCIII), adiponectin, resistin, interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-a) which are thought to have a role in the deterioration of glucose and lipid metabolism in MetS. Methods: This clinical experimental study consists of 3 groups. The MetS+E (n=24) group, which included the participants who agreed to participate in the exercise program in addition to their medical treatment, the MetS (n=23) group who received medical treatment but did not exercise, and the Control+E (n=25) group, which included healthy volunteers who had the same protocol as MetS+E. ApoE, ApoCIII, adiponectin, resistin, IL-6, and TNF-a plasma levels of all participants were measured both at the beginning of the study and at the end of the protocol. Results: At the end of the study we reached the following findings; insulin and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) levels decreased in exercise groups (p=0,03). ApoCIII levels are increased all the groups after the study (p Conclusion:Training showed metabolic, anti-inflammatory and physical improvements independent of ApoE and ApoCIII in those with MetS. Keywords: Adipokines, Apolioprotein Clll, Apolipoprotein E, exercise, metabolic syndrome.