학술논문
Microtubule polarity and dynamics in the control of organelle positioning, segregation, and cytokinesis in the trypanosome cell cycle
Document Type
Academic Journal
Source
The Journal of Cell Biology. March, 1995, Vol. 128 Issue 5-6, p1163, 10 p.
Subject
Language
ISSN
0021-9525
Abstract
A study of the association between the distinct localization of organelles, their mitosis, segregation, cytokinesis and microtubule cytoskeleton morphogenesis through three different assays confirms the presence of microtubule polarity, with the positive ends being present at the posterior end of the cell. Organelle position measurements indicate the presence of coordinate movement and a correlation with overall cell extension. The use of the antimicrotubule drug rhizoxin for the suppression of microtubule dynamics at the time of cytoskeletal morphogenesis reveals the existence of a new process that divides the cell into a nucleated section and a kinetoplast- and mitochondrion-containing cytoplast, which is anucleate and flagellated.