학술논문
Histopathologic Features of Breast Tissue From Transgender Men and Their Associations With Androgen Therapy
ORIGINAL ARTICLE
ORIGINAL ARTICLE
Document Type
Academic Journal
Source
American Journal of Clinical Pathology. January 2023, Vol. 159 Issue 1, p43, 10 p.
Subject
Language
English
ISSN
0002-9173
Abstract
INTRODUCTION A growing number of individuals identify as transgender in the United States, and as a result, the number of patients seeking gender-affirming surgery has risen considerably in recent years. [...]
Objectives: To assess the histopathologic features of breast tissue of transgender men (TM) undergoing gender-affirming bilateral mastectomies in relation to androgen therapy (AT). Methods: We reviewed 374 transgender bilateral mastectomy cases from 2017 to 2020. Of these, 314 (84.4%) patients received preoperative AT. We compared these with 127 cases of cisgender females undergoing elective breast reduction. Results: Breast specimens from TM on AT, compared with cisgender women, showed a median higher gross percentage of fibrous tissue (P Conclusions: In this study, breast specimens from TM, particularly with a history of AT, had a higher proportion of fibrous tissue, fewer lobules, and a higher degree of lobular atrophy than cisgender females. Rare cases of atypia were not predicted by preoperative imaging or gross findings, supporting routine microscopic evaluation of these specimens. KEY WORDS Breast; Transgender men; Genderaffirming mastectomy; Androgen therapy
Objectives: To assess the histopathologic features of breast tissue of transgender men (TM) undergoing gender-affirming bilateral mastectomies in relation to androgen therapy (AT). Methods: We reviewed 374 transgender bilateral mastectomy cases from 2017 to 2020. Of these, 314 (84.4%) patients received preoperative AT. We compared these with 127 cases of cisgender females undergoing elective breast reduction. Results: Breast specimens from TM on AT, compared with cisgender women, showed a median higher gross percentage of fibrous tissue (P Conclusions: In this study, breast specimens from TM, particularly with a history of AT, had a higher proportion of fibrous tissue, fewer lobules, and a higher degree of lobular atrophy than cisgender females. Rare cases of atypia were not predicted by preoperative imaging or gross findings, supporting routine microscopic evaluation of these specimens. KEY WORDS Breast; Transgender men; Genderaffirming mastectomy; Androgen therapy