부산대학교 도서관

Background: Inflammation and oxidative stress are important factors associated with chronic disease such as essential hypertension (HTN) and type 2 diabetes mellitus (T2DM). However, the association of inflammation and oxidative stress in HTN with T2DM as a comorbidity is inconclusive due to the multifactorial nature of these cardiometabolic diseases. Methodology: The influence of pathophysiological factors include genetics, age of patient, and disease progression change throughout the lifespan and require further investigation. The study population included 256 participants attending a rural health screening program who were tested for markers of inflammation, oxidative stress, and coagulation/fibrinolysis. Demographic and clinical variables included, age, gender, systolic and diastolic blood pressures, blood glucose, hemoglobin A1c, estimated glomerular filtration rate, and cholesterol profile. Data were tested for normality, and nonparametric statistics were applied to analyze the sample with significance set at p Results: Of the inflammatory markers, interleukin-1 P (IL-1[beta]) and IL-10 were significantly different between the control and hypertensive group (p Conclusion: This study demonstrated that 8-iso-[PGF.sup.2][alpha] and erythrocyte GSH may be clinically useful for assessing HTN and HTN with T2DM as a comorbidity, while significant changes in the inflammatory profile were also observed with HTN progression. Keywords: hypertension, type 2 diabetes mellitus, inflammation, oxidative stress, biomarkers
Introduction Hypertension (HTN) is a public health problem which affects over 1 billion people world-wide. (1) HTN is often associated with type 2 diabetes mellitus (T2DM), approximately 75% of people [...]