학술논문
Transcriptome-guided characterization of genomic rearrangements in a breast cancer cell line
Document Type
Author abstract
Report
Report
Author
Source
Proceedings of the National Academy of Sciences of the United States. Feb 10, 2009, Vol. 106 Issue 6, p1886, 6 p.
Subject
Language
English
ISSN
0027-8424
Abstract
We have identified new genomic alterations in the breast cancer cell line HCC1954, using high-throughput transcriptome sequencing. With 120 Mb of cDNA sequences, we were able to identify genomic rearrangement events leading to fusions or truncations of genes including MRE11 and NSD1, genes already implicated in oncogenesis, and 7 rearrangements involving other additional genes. This approach demonstrates that high-throughput transcriptome sequencing is an effective strategy for the characterization of genomic rearrangements in cancers. cancer genome | transcriptome sequencing