학술논문
Yeast FKBP-13 is a membrane-associated FK506-binding protein encoded by the nonessential gene FKB2
Document Type
Academic Journal
Author
Source
Proceedings of the National Academy of Sciences of the United States. August 15, 1992, Vol. 89 Issue 16, p7471, 5 p. table
Subject
Language
ISSN
0027-8424
Abstract
The isolation and characterization of a second yeast FK506-binding protein (FKBP) from strains lacking yFKBP-12 as well as the cloning, sequencing and disruption of its gene, FKB2 were presented. yFKBP-13 was cloned and sequenced to make a product that closely resembles the membrane-associated human FKBP-13 which also possesses a signal peptide. fkb2 mutants were found to be viable and has unaltered sensitivity to FK506.