학술논문
Association of Primary Sarcopenia with Serum MMP2, TIMP2 Levels, and MMP2/TIMP2 Ratio
ORIGINAL RESEARCH
ORIGINAL RESEARCH
Document Type
Academic Journal
Author
Source
European Journal of Geriatrics and Gerontology. August 2022, Vol. 4 Issue 2, p46, 6 p.
Subject
Language
English
ISSN
2687-2625
Abstract
Introduction Sarcopenia is a complex and multifactorial disease characterized with a decrease in muscle mass and muscle strength, that causes decreased mobility, increased risk of falling, decreased quality of life [...]
Objective: Our aim is to evaluate the association of serum matrix metalloproteinase (MMP2), tissue inhibitor of metalloproteinase (TIMP2) levels, MMP2/TIMP2 ratio, SARC-F with primary sarcopenia, and to investigate the coexistence of primary sarcopenia and osteoporosis in geriatric population. Materials and Methods: A total of 80 geriatric patients (41 sarcopenic patients) were included in the study. Patients with secondary sarcopenia were excluded. By SARC-F questionnaire, patients who were at risk for sarcopenia were found as mentioned by EWGSOP2. Serum MMP2 and TIMP2 levels were analyzed by ELISA method. Dual energy X-ray absorptiometry (DEXA) was used for the diagnosis of osteoporosis. Results: The SARC-F score of the sarcopenia group was statistically significantly higher and the incidence of osteoporosis was higher in this group than the group without sarcopenia (p4 were 58.5% and 87.2%, respectively. Conclusion: Our study supports the usage of SARC-F in finding of primary sarcopenia cases. We have revealed that serum MMP2, TIMP2 level and MMP2/TIMP2 ratio are not suitable markers for diagnosing sarcopenia. Since the coexistence of osteoporosis and sarcopenia is common in the elderly, they should be considered together. Keywords: Sarcopenia, MMP2, TIMP2, SARC-F, osteoporosis
Objective: Our aim is to evaluate the association of serum matrix metalloproteinase (MMP2), tissue inhibitor of metalloproteinase (TIMP2) levels, MMP2/TIMP2 ratio, SARC-F with primary sarcopenia, and to investigate the coexistence of primary sarcopenia and osteoporosis in geriatric population. Materials and Methods: A total of 80 geriatric patients (41 sarcopenic patients) were included in the study. Patients with secondary sarcopenia were excluded. By SARC-F questionnaire, patients who were at risk for sarcopenia were found as mentioned by EWGSOP2. Serum MMP2 and TIMP2 levels were analyzed by ELISA method. Dual energy X-ray absorptiometry (DEXA) was used for the diagnosis of osteoporosis. Results: The SARC-F score of the sarcopenia group was statistically significantly higher and the incidence of osteoporosis was higher in this group than the group without sarcopenia (p4 were 58.5% and 87.2%, respectively. Conclusion: Our study supports the usage of SARC-F in finding of primary sarcopenia cases. We have revealed that serum MMP2, TIMP2 level and MMP2/TIMP2 ratio are not suitable markers for diagnosing sarcopenia. Since the coexistence of osteoporosis and sarcopenia is common in the elderly, they should be considered together. Keywords: Sarcopenia, MMP2, TIMP2, SARC-F, osteoporosis