부산대학교 도서관

Neuropilins (NRPs) are transmembrane proteins involved in vascular and nervous system development by regulating angiogenesis and axon guidance cues. Several published reports have established their role in tumorigenesis. NRPs are detectable in tumor cells of several cancer types and participate in cancer progression. NRP2 is also expressed in endothelial and immune cells in the tumor microenvironment and promotes functions such as lymphangiogenesis and immune suppression important for cancer progression. In this review, we have taken a comprehensive approach to discussing various aspects of NRP2-signaling in cancer, including its regulation, functional significance in cancer progression, and how we could utilize our current knowledge to advance the studies and target NRP2 to develop effective cancer therapies.
Author(s): Ridwan Islam [sup.1], Juhi Mishra [sup.1], Sanika Bodas [sup.2], Sreyashi Bhattacharya [sup.1], Surinder K. Batra [sup.1], Samikshan Dutta [sup.1], Kaustubh Datta [sup.1] Author Affiliations: (1) grid.266813.8, 0000 0001 0666 [...]