학술논문
Recombinant human Fab fragments neutralize human type 1 immunodeficiency virus in vitro
Document Type
Academic Journal
Author
Source
Proceedings of the National Academy of Sciences of the United States. Oct 1, 1992, Vol. 89 Issue 19, p9339, 5 p.
Subject
Language
ISSN
0027-8424
Abstract
Combinatorial libraries are sources of Fab antibodies which have been useful in the elucidation of the neutralization of the human immunodeficiency virus (HIV). Twenty recombinant human Fab fragments against glycoprotein 120 (gp120) of HIV-1 were assessed for the ability to neutralize MN and IIIB strains of the virus. The results showed that not all the Fab fragments could neutralize the virus, although a group of sequence-related fragments could. However, all of the Fab fragments were competitive with CD4 for binding with gp120. These results imply that a large portion of the antigenic structure of gp120 can elicit antibodies but with only limited antiviral activities.