학술논문
Water T2 could predict functional decline in patients with dysferlinopathy
Document Type
Report
Author
Moore, Ursula; Araújo, Ericky Caldas De Almeida; Reyngoudt, Harmen; Gordish‐Dressman, Heather; Smith, Fiona E.; Wilson, Ian; James, Meredith; Mayhew, Anna; Rufibach, Laura; Day, John W.; Jones, Kristi J.; Bharucha‐Goebel, Diana X.; Salort‐Campana, Emmanuelle; Pestronk, Alan; Walter, Maggie C.; Paradas, Carmen; Stojkovic, Tanya; Mori‐Yoshimura, Madoka; Bravver, Elena; Pegoraro, Elena; Mendell, Jerry R.; Bushby, Kate; Blamire, Andrew M.; Straub, Volker; Carlier, Pierre G.; Diaz‐Manera, Jordi
Source
Journal of Cachexia, Sarcopenia and Muscle. December 2022, Vol. 13 Issue 6, p2888, 10 p.
Subject
Language
English
Abstract
Introduction Predicting functional decline in muscular dystrophies is a difficult task. There are many paediatric and adult onset forms of muscular dystrophy and they display highly variable rates of disease [...]
: Background: Water T2 (T2[sub.H2O]) mapping is increasingly being used in muscular dystrophies to assess active muscle damage. It has been suggested as a surrogate outcome measure for clinical trials. Here, we investigated the prognostic utility of T2[sub.H2O] to identify changes in muscle function over time in limb girdle muscular dystrophies. Methods: Patients with genetically confirmed dysferlinopathy were assessed as part of the Jain Foundation Clinical Outcomes Study in dysferlinopathy. The cohort included 18 patients from two sites, both equipped with 3‐tesla magnetic resonance imaging (MRI) systems from the same vendor. T2[sub.H2O] value was defined as higher or lower than the median in each muscle bilaterally. The degree of deterioration on four functional tests over 3 years was assessed in a linear model against covariates of high or low T2[sub.H2O] at baseline, age, disease duration, and baseline function. Results: A higher T2[sub.H2O] at baseline significantly correlated with a greater decline on functional tests in 21 out of 35 muscles and was never associated with slower decline. Higher baseline T2[sub.H2O] in adductor magnus, vastus intermedius, vastus lateralis, and vastus medialis were the most sensitive, being associated bilaterally with greater decline in multiple timed tests. Patients with a higher than median baseline T2[sub.H2O] (>40.6 ms) in the right vastus medialis deteriorated 11 points more on the North Star Ambulatory Assessment for Dysferlinopathy and lost an additional 86 m on the 6‐min walk than those with a lower T2[sub.H2O] ( Conclusions: In dysferlinopathy, T2[sub.H2O] did not correlate with current functional ability. However, T2[sub.H2O] at baseline was higher in patients who worsened more rapidly on functional tests. This suggests that inter‐patient differences in functional decline over time may be, in part, explained by different severities of the active muscle damage, assessed by T2[sub.H2O] measure at baseline. Significant challenges remain in standardizing T2[sub.H2O] values across sites to allow determining globally applicable thresholds. The results from the present work are encouraging and suggest that T2[sub.H2O] could be used to improve prognostication, patient selection, and disease modelling for clinical trials.
: Background: Water T2 (T2[sub.H2O]) mapping is increasingly being used in muscular dystrophies to assess active muscle damage. It has been suggested as a surrogate outcome measure for clinical trials. Here, we investigated the prognostic utility of T2[sub.H2O] to identify changes in muscle function over time in limb girdle muscular dystrophies. Methods: Patients with genetically confirmed dysferlinopathy were assessed as part of the Jain Foundation Clinical Outcomes Study in dysferlinopathy. The cohort included 18 patients from two sites, both equipped with 3‐tesla magnetic resonance imaging (MRI) systems from the same vendor. T2[sub.H2O] value was defined as higher or lower than the median in each muscle bilaterally. The degree of deterioration on four functional tests over 3 years was assessed in a linear model against covariates of high or low T2[sub.H2O] at baseline, age, disease duration, and baseline function. Results: A higher T2[sub.H2O] at baseline significantly correlated with a greater decline on functional tests in 21 out of 35 muscles and was never associated with slower decline. Higher baseline T2[sub.H2O] in adductor magnus, vastus intermedius, vastus lateralis, and vastus medialis were the most sensitive, being associated bilaterally with greater decline in multiple timed tests. Patients with a higher than median baseline T2[sub.H2O] (>40.6 ms) in the right vastus medialis deteriorated 11 points more on the North Star Ambulatory Assessment for Dysferlinopathy and lost an additional 86 m on the 6‐min walk than those with a lower T2[sub.H2O] ( Conclusions: In dysferlinopathy, T2[sub.H2O] did not correlate with current functional ability. However, T2[sub.H2O] at baseline was higher in patients who worsened more rapidly on functional tests. This suggests that inter‐patient differences in functional decline over time may be, in part, explained by different severities of the active muscle damage, assessed by T2[sub.H2O] measure at baseline. Significant challenges remain in standardizing T2[sub.H2O] values across sites to allow determining globally applicable thresholds. The results from the present work are encouraging and suggest that T2[sub.H2O] could be used to improve prognostication, patient selection, and disease modelling for clinical trials.