부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.canlet.2009.03.037 Byline: Muhammad Nadeem Aslam (a), Narasimharao Bhagavathula (a), Tejaswi Paruchuri (a), Xin Hu (b), Subhas Chakrabarty (b), James Varani (a) Keywords: Calcium; Colon cancer; Lithothamnion calcareum; Red algae extract Abstract: Proliferation and differentiation were assessed in a series of human colon carcinoma cell lines in response to a mineral-rich extract derived from the red marine algae, Lithothamnion calcareum. The extract contains 12% Ca.sup.2+, 1% Mg.sup.2+, and detectable amounts of 72 trace elements, but essentially no organic material. The red algae extract was as effective as inorganic Ca.sup.2+ alone in suppressing growth and inducing differentiation of colon carcinoma cells that are responsive to a physiological level of extracellular Ca.sup.2+ (1.4mM). However, with cells that are resistant to Ca.sup.2+ alone, the extract was still able to reduce proliferation and stimulate differentiation. Author Affiliation: (a) Department of Pathology, University of Michigan Medical School, 1301 Catherine Street, SPC 5602, Ann Arbor, MI 48109, USA (b) Department of Medical Microbiology, Immunology and Cell Biology, Southern Illinois University School of Medicine, Springfield, IL 62794-9677, USA Article History: Received 13 November 2008; Revised 17 March 2009; Accepted 30 March 2009