학술논문
A faster-acting and more potent form of tissue plasminogen activator
Document Type
Academic Journal
Author
Source
Proceedings of the National Academy of Sciences of the United States. April 26, 1994, Vol. 91 Issue 9, p3670, 5 p.
Subject
Language
ISSN
0027-8424
Abstract
Preservation of full fibrinolytic activity under reduced clearance is achieved by a combination of mutations at distinct sites on tissue plasminogen activator (tPA). An additional mutation, N117Q(N), is applied to maintain fibrinolytic activity. A more potent variant (TNK-tPA) exhibiting advantages for clinically-induced thrombolysis is produced.