학술논문
Epstein Virus Barr-Positive Diffuse Large B-Cell Lymphoma Associated with Hemophagocytic Lymphohistiocytosis
BRIEF REPORT
BRIEF REPORT
Document Type
Clinical report
Author
Source
Journal of Neuropathology and Experimental Neurology. August 2020, Vol. 79 Issue 8, p915, 6 p.
Subject
Language
English
ISSN
0022-3069
Abstract
INTRODUCTION Hemophagocytic lymphohistiocytosis (HLH) is a rare disease in which macrophages/lymphocytes are inappropriately activated resulting in phagocytosis of all bone marrow-derived cells (1). This inappropriate activation leads to overproduction of [...]
Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal disease if not diagnosed and treated promptly. HLH can be due to genetic factors or infections, malignancies and collagen-associated vascular diseases. Malignancy-associated HLH is not only more common in the setting of T/NK-cell lymphomas, but may also rarely be seen in the setting of B-cell lymphoma. Here, we describe a unique case of a patient who initially was diagnosed with HLH secondary to Epstein Barr virus (EBV) infection and subsequently developed EBV-positive diffuse large B-cell lymphoma affecting the brain. This case highlights the spectrum of findings associated with EBV infections and the challenges in diagnosing underlying diseases associated with HLH. Key Words: Epstein Barr virus (EBV), Hemophagocytic lympho-histiocytosis (HLH).
Hemophagocytic lymphohistiocytosis (HLH) is a rare and often fatal disease if not diagnosed and treated promptly. HLH can be due to genetic factors or infections, malignancies and collagen-associated vascular diseases. Malignancy-associated HLH is not only more common in the setting of T/NK-cell lymphomas, but may also rarely be seen in the setting of B-cell lymphoma. Here, we describe a unique case of a patient who initially was diagnosed with HLH secondary to Epstein Barr virus (EBV) infection and subsequently developed EBV-positive diffuse large B-cell lymphoma affecting the brain. This case highlights the spectrum of findings associated with EBV infections and the challenges in diagnosing underlying diseases associated with HLH. Key Words: Epstein Barr virus (EBV), Hemophagocytic lympho-histiocytosis (HLH).