학술논문
Receptor Isoforms That Mediate Estrogen and Progestagen Action in the Female Lower Urinary Tract
Document Type
Academic Journal
Source
The Journal of Urology. March, 2009, Vol. 181 Issue 3, p1474, 9 p.
Subject
Language
English
ISSN
0022-5347
Abstract
To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.juro.2008.10.104 Byline: Douglas G. Tincello, Anthony H. Taylor, Susan M. Spurling, Stephen C. Bell Keywords: bladder; urethra; receptors; estrogen; receptors; progesterone; urothelium Abbreviations: AMV, avian myeloblastosis virus; ER, estrogen receptor; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; HRT, hormone replacement therapy; PR, progesterone receptor; RT-PCR, reverse transcriptase-polymerase chain reaction Abstract: Bladder symptoms can be ameliorated by sex steroids but to our knowledge the mechanism of action is unknown. Previous studies of steroid receptor expression in the bladder did not indicate receptor subtype expression. We report the distribution of estrogen and progesterone receptor isoforms in the female lower urinary tract. Author Affiliation: Reproductive Sciences Section, Department of Cancer Studies and Molecular Medicine, Faculty of Medicine and Biological Sciences, University of Leicester, Leicester, United Kingdom Article History: Received 14 May 2008 Article Note: (footnote) Study received local research ethics committee approval.