학술논문
Design, synthesis, and characterization of 4-ester C12, a model for backbone hydrogen bonding in protein alpha-helices
Document Type
Academic Journal
Source
Journal of the American Chemical Society. Dec 13, 2000, Vol. 122 Issue 49, p12079, 4 p.
Subject
Language
English
ISSN
0002-7863
Abstract
The multiple ester bonds are incorporated into a polypeptide by total chemical synthesis to synthesize a folded, functional protein. The study shows that the formation of multiple consecutive hydrogen bonds is not required for the folding of protein alpha-helices.