학술논문
RP-LC Analysis and Hydrolytic Degradation Profile of Racecadotril
Document Type
Report
Source
Chromatographia. Oct, 2008, Vol. 68 Issue 1, p641, 7 p.
Subject
Language
English
ISSN
0009-5893
Abstract
A sensitive, stability-indicating liquid-chromatographic method for analysis of racecadotril in the presence of its degradation products has been developed and validated. Efficient chromatographic separation was achieved on a C.sub.18 column with a simple isocratic mobile phase--60:40 methanol--water. Quantification was by photo-diode array (PDA) detection at 220 nm. The linearity of the method was excellent over the range 1--32 ug mL.sup.-1. The method was sensitive, with low limits of detection (20 ng mL.sup.-1) and quantification (100 ng mL.sup.-1). The recovery of the method was consistently good (98.7--100.9%), with low (