학술논문
Capsaicin: Plants of the Genus Capsicum and Positive Effect of Oriental Spice on Skin Health
Document Type
Report
Author
Source
Skin Pharmacology and Physiology. February 1, 2021, Vol. 33 Issue 6, p331, 11 p.
Subject
Language
English
ISSN
1660-5527
Abstract
Author(s): Shahnai Basharat (corresponding author) [a]; Syed Amir Gilani [b]; Faiza Iftikhar [a]; Mian Anjum Murtaza [c]; Ayesha Basharat [d]; Ahsan Sattar [e]; Muhammad Mustafa Qamar [f]; Muhammad Ali [g] [...]
Background: Capsaicin, the main pungent ingredient in hot chili peppers, causes excitation of small sensory neurons. It also provides the basic pungent flavor in Capsicum fruits. Summary: Capsaicin plays a vital role as an agonist for the TRPV1 (transient receptor potential cation channel, subfamily V, member 1) receptor. TRPV1 is essential for the reduction of oxidative stress, pain sensations, and inflammation. Therefore, it has many pros related to health issue. Activation and positive impact of TRPV1 via capsaicin has been studied in various dermatological conditions and in other skin-related issues. Past studies documented that capsaicin plays a vital role in the prevention of atopic dermatitis as well as psoriasis. Moreover, TRPV1 is also very important for skin health because it acts as a capsaicin receptor. It is found in nociceptive nerve fibers and nonneural structures. It prompts the release of a compound that is involved in communicating pain between the spinal cord nerves and other parts of the body. Key Messages: Here, we summarize the growing evidence for the beneficial role of capsaicin and TRPV1 and how they help in the relief of skin diseases such as inflammation, permeation, dysfunction, atopic dermatitis, and psoriasis and in pain amplification syndrome. Keywords: Transient receptor potential cation channel, subfamily V, member 1, Capsicum, Capsaicin, Psoriasis, Skin, Atopic dermatitis
Background: Capsaicin, the main pungent ingredient in hot chili peppers, causes excitation of small sensory neurons. It also provides the basic pungent flavor in Capsicum fruits. Summary: Capsaicin plays a vital role as an agonist for the TRPV1 (transient receptor potential cation channel, subfamily V, member 1) receptor. TRPV1 is essential for the reduction of oxidative stress, pain sensations, and inflammation. Therefore, it has many pros related to health issue. Activation and positive impact of TRPV1 via capsaicin has been studied in various dermatological conditions and in other skin-related issues. Past studies documented that capsaicin plays a vital role in the prevention of atopic dermatitis as well as psoriasis. Moreover, TRPV1 is also very important for skin health because it acts as a capsaicin receptor. It is found in nociceptive nerve fibers and nonneural structures. It prompts the release of a compound that is involved in communicating pain between the spinal cord nerves and other parts of the body. Key Messages: Here, we summarize the growing evidence for the beneficial role of capsaicin and TRPV1 and how they help in the relief of skin diseases such as inflammation, permeation, dysfunction, atopic dermatitis, and psoriasis and in pain amplification syndrome. Keywords: Transient receptor potential cation channel, subfamily V, member 1, Capsicum, Capsaicin, Psoriasis, Skin, Atopic dermatitis