학술논문

1 kHz fixed-target serial crystallography using a multilayer monochromator and an integrating pixel detector
Document Type
Academic Journal
Source
International Union of Crystallography Journal. September, 2019, Vol. 6 Issue 5, p927, 11 p.
Subject
Germany
Language
English
ISSN
2052-2525
Abstract
Reliable sample delivery and efficient use of limited beam time have remained bottlenecks for serial crystallography (SX). Using a high-intensity polychromatic X-ray beam in combination with a newly developed charge-integrating JUNGFRAU detector, we have applied the method of fixed-target SX to collect data at a rate of 1 kHz at a synchrotron-radiation facility. According to our data analysis for the given experimental conditions, only about 3 000 diffraction patterns are required for a high-quality diffraction dataset. With indexing rates of up to 25%, recording of such a dataset takes less than 30 s.
1. Introduction Serial crystallography (SX) is based on merging data from still diffraction patterns collected from several tens to several hundreds of thousands of crystals into a complete set of [...]