학술논문
Koronavirus Hastaligi-2019 Pandemisinde Ayirici Tanida Akilda Tutulmasi Gereken Hastalik: Kirim-Kongo Kanamali Atesi/Crimean-Congo Hemorrhagic Fever in Differential Diagnosis During the Coronavirus Disease-2019 Pandemic
Document Type
Disease/Disorder overview
Source
Turkish Journal of Parasitology. March 2022, Vol. 46 Issue 1, p50, 4 p.
Subject
Language
English
ISSN
1300-6320
Abstract
GIRIS Kirim-Kongo Kanamali Atesi (KKKA), viral hemorajik atesler gurubundan bir hastaliktir. Hastaligin etkeni olan KKKA virusu Bunyaviridae ailesinin nairovirus genusundan bir RNA virusudur. Hastalik enfekte Hyalomma cinsi kenelerin kan emdigi [...]
Amac: Kirim-Kongo Kanamali Atesi (KKKA), viral hemorajik atesler grubundan bir hastaliktir ve ulkemizde belli bolgelerde endemik olarak gorulmektedir. Bu calismada Koronavirus hastaligi-2019 (COVID-19) pandemisi doneminde KKKA tanisi alan hastalarimizin demografik, klinik ve laboratuvar bulgulari incelenmis ve ayirici taniya dikkat cekilmistir. Yontemler: Calismamiza COVID-19 pandemisinin ulkemizdeki baslangic tarihi olan 11 Mart 2020 tarihinden sonra klinigimize sevk veya direkt basvuru seklinde yatirilan ve KKKA tanisi ters transkripsiyon-polimeraz zincir reaksiyonu ile viral-RNA ya da enzim bagli immunosorbent deneyi ile immunoglobulin M antikorlari gosterilerek dogrulanan ve 18 yas ustu olan 12 hasta dahil edildi. Epidemiyolojik ozellikleri, klinik ve laboratuvar bulgulari, tedavi ve prognozlari irdelendi. Bulgular: Hastalarin 10'u (%83,3) erkek, 2'si (%16,7) kadin, medyan yas (interquartile range) degeri ise 51 (27-64) yil idi. Hastalarin 11'i (%91,7) kirsal bolgede yasamaktaydi, 7'sinde (%58,3) ise kene ile temas oykusu vardi. Bes hasta dis merkezde COVID-19 on tanisi ile yatirilip, klinik ve laboratuvar kotulesmesi uzerine merkezimize sevk edildi. En sik gorulen semptomlar istahsizlik, bas agrisi, ates, halsizlik ve kas-eklem agrisi idi. Besi dis merkezden sevkli olarak gelen alti hastaya COVID-19 suphesiyle toraks bilgisayarli tomografisi (BT) cekildi ve hicbirinde toraks BT'de patolojik bulgu saptanmadi. Sonuc: Onumuzdeki aylarda asi uygulamalarinin da katkisiyla COVID-19 pandemisinin sona erecegi dusunulse de sporadik olgulara uzun sure rastlanacagi ongorulebilir. Klinisyenler COVID-19'a benzer klinik ve laboratuvar bulgulari gosteren KKKA'yi ayirici tanida akilda bulundurmalidir. Endemik bolgelerde ko-enfeksiyonlarin da gorulebilecegi unutulmamalidir. Anahtar Kelimeler: Kirim-Kongo Kanamali Atesi, COVID-19 pandemisi, lenfopeni, kene Objective: Crimean-Congo Hemorrhagic Fever (CCHF) is a disease of the viral hemorrhagic fever group and is endemic in certain regions in Turkey. Here, the demographic, clinical, and laboratory findings of patients diagnosed with CCHF during the Coronavirus disease-2019 (COVID-19) pandemic were examined, and differential diagnosis was stressed. Methods: This study comprised 12 patients over the age of 18 who were admitted to our clinic after the onset of the COVID-19 pandemic on March 11, 2020 and whose CCHF diagnosis was confirmed by reverse transcription-polymerase chain reaction with viral-RNA or enzyme-linked immunosorbent assay with immunoglobulin M antibodies. Epidemiological, clinical, and laboratory findings as well as treatment and prognosis of the patients were investigated. Results: Of the 12 cases, 10 (83.3%) were men and 2 (16.7%) were women. The median (interquartile range) age was 51 (27-64) years. Eleven (91.7%) patients lived in rural regions, and seven (58.3%) had a history of tick contact. Five patients were hospitalized in an external center with a preliminary diagnosis of COVID-19 and transferred to our center due to clinical and laboratory deterioration. Loss of appetite, headache, fever, weakness, and muscle-joint pain were the most common complaints of the patients. Following the suspicion of COVID-19, thoracic computed tomography (CT) was performed in six patients, five of whom were transferred to an external center. None of the patients had any pathological findings following thoracic CT. Conclusion: Although it is thought that the COVID-19 pandemic will end in the following months owing to vaccine applications, it can be predicted that sporadic cases will still occur for a long time. Therefore, clinicians should take CCHF into consideration in their differential diagnosis. Also, it should be remembered that co-infections can be observed in endemic areas. Keywords: Crimean-Congo Hemorrhagic Fever, COVID-19 pandemic, lymphopenia, tick
Amac: Kirim-Kongo Kanamali Atesi (KKKA), viral hemorajik atesler grubundan bir hastaliktir ve ulkemizde belli bolgelerde endemik olarak gorulmektedir. Bu calismada Koronavirus hastaligi-2019 (COVID-19) pandemisi doneminde KKKA tanisi alan hastalarimizin demografik, klinik ve laboratuvar bulgulari incelenmis ve ayirici taniya dikkat cekilmistir. Yontemler: Calismamiza COVID-19 pandemisinin ulkemizdeki baslangic tarihi olan 11 Mart 2020 tarihinden sonra klinigimize sevk veya direkt basvuru seklinde yatirilan ve KKKA tanisi ters transkripsiyon-polimeraz zincir reaksiyonu ile viral-RNA ya da enzim bagli immunosorbent deneyi ile immunoglobulin M antikorlari gosterilerek dogrulanan ve 18 yas ustu olan 12 hasta dahil edildi. Epidemiyolojik ozellikleri, klinik ve laboratuvar bulgulari, tedavi ve prognozlari irdelendi. Bulgular: Hastalarin 10'u (%83,3) erkek, 2'si (%16,7) kadin, medyan yas (interquartile range) degeri ise 51 (27-64) yil idi. Hastalarin 11'i (%91,7) kirsal bolgede yasamaktaydi, 7'sinde (%58,3) ise kene ile temas oykusu vardi. Bes hasta dis merkezde COVID-19 on tanisi ile yatirilip, klinik ve laboratuvar kotulesmesi uzerine merkezimize sevk edildi. En sik gorulen semptomlar istahsizlik, bas agrisi, ates, halsizlik ve kas-eklem agrisi idi. Besi dis merkezden sevkli olarak gelen alti hastaya COVID-19 suphesiyle toraks bilgisayarli tomografisi (BT) cekildi ve hicbirinde toraks BT'de patolojik bulgu saptanmadi. Sonuc: Onumuzdeki aylarda asi uygulamalarinin da katkisiyla COVID-19 pandemisinin sona erecegi dusunulse de sporadik olgulara uzun sure rastlanacagi ongorulebilir. Klinisyenler COVID-19'a benzer klinik ve laboratuvar bulgulari gosteren KKKA'yi ayirici tanida akilda bulundurmalidir. Endemik bolgelerde ko-enfeksiyonlarin da gorulebilecegi unutulmamalidir. Anahtar Kelimeler: Kirim-Kongo Kanamali Atesi, COVID-19 pandemisi, lenfopeni, kene Objective: Crimean-Congo Hemorrhagic Fever (CCHF) is a disease of the viral hemorrhagic fever group and is endemic in certain regions in Turkey. Here, the demographic, clinical, and laboratory findings of patients diagnosed with CCHF during the Coronavirus disease-2019 (COVID-19) pandemic were examined, and differential diagnosis was stressed. Methods: This study comprised 12 patients over the age of 18 who were admitted to our clinic after the onset of the COVID-19 pandemic on March 11, 2020 and whose CCHF diagnosis was confirmed by reverse transcription-polymerase chain reaction with viral-RNA or enzyme-linked immunosorbent assay with immunoglobulin M antibodies. Epidemiological, clinical, and laboratory findings as well as treatment and prognosis of the patients were investigated. Results: Of the 12 cases, 10 (83.3%) were men and 2 (16.7%) were women. The median (interquartile range) age was 51 (27-64) years. Eleven (91.7%) patients lived in rural regions, and seven (58.3%) had a history of tick contact. Five patients were hospitalized in an external center with a preliminary diagnosis of COVID-19 and transferred to our center due to clinical and laboratory deterioration. Loss of appetite, headache, fever, weakness, and muscle-joint pain were the most common complaints of the patients. Following the suspicion of COVID-19, thoracic computed tomography (CT) was performed in six patients, five of whom were transferred to an external center. None of the patients had any pathological findings following thoracic CT. Conclusion: Although it is thought that the COVID-19 pandemic will end in the following months owing to vaccine applications, it can be predicted that sporadic cases will still occur for a long time. Therefore, clinicians should take CCHF into consideration in their differential diagnosis. Also, it should be remembered that co-infections can be observed in endemic areas. Keywords: Crimean-Congo Hemorrhagic Fever, COVID-19 pandemic, lymphopenia, tick