학술논문
Declining serum total cholesterol levels among US adults: the National Health and Nutrition Examination Surveys
Document Type
Academic Journal
Author
Source
JAMA, The Journal of the American Medical Association. June 16, 1993, Vol. v269 Issue n23, p3002, 7 p.
Subject
Language
ISSN
0098-7484
Abstract
Blood cholesterol levels appear to have substantially declined among US adults since 1960. The goal of the Department of Health and Human Services is to lower the average adult blood cholesterol level to no more than 200 milligrams per deciliter (mg/dL). Estimates of total blood cholesterol are based on data from four national studies conducted between 1960 and 1991. Between 6,000 and 13,200 people aged 20 to 74 participated in each study, which consisted of a home interview and a medical examination. Between 1988 and 1991, the average cholesterol level among all adults was 206 mg/dL. Between 1960 and 1962, the national average was 220 mg/dL. Most of the decline in total blood cholesterol levels appears to be due to a reduction in the levels of low-density lipoproteins, which dropped an average of 8 mg/dL between 1976 and 1991. More than half the observed decline in blood cholesterol levels occurred between 1976 and 1991, suggesting that public health efforts to lower cholesterol have influenced the population.
Objective. -- To examine the secular trend in serum total cholesterol levels of the US adult population. Design. -- Nationally representative cross-sectional surveys with both an inperson interview and a medical examination that included the measurement of blood lipid levels. Setting/Participants. Between 6000 and 13000 adults aged 20 through 74 years examined in each of four separate national surveys during 1960 through 1962, 1971 through 1974, 1976 through 1980, and 1988 through 1991. Results. -- Mean serum total cholesterol levels in US adults aged 20 through 74 years have consistently declined over the time period 1960 through 1991. More than half of the decline occurred during the time period 1976 through 1991. This decline occurred across the entire distribution of serum cholesterol levels and in all age-sex groups. High-density lipoprotein cholesterol and very low-density lipoprotein cholesterol levels have not changed, suggesting that the decline in total cholesterol levels is due to a decline in low-density lipoprotein cholesterol levels. Conclusions. -- These results documents a continuing and substantial decline in serum cholesterol levels among US adults. They suggest that public health programs, designed to reduce cholesterol levels, are proving successful. The observed downward trend in serum cholesterol levels has coincided with a continuing declined in coronary heart disease mortality. These observations suggest that the Healthy People 2000 goal of reducing the mean serum cholesterol level of US adults to no more than 200 mg/dL (5.17 mmol/L) is attainable. JAMA. 1993;269:3002-3008)
Objective. -- To examine the secular trend in serum total cholesterol levels of the US adult population. Design. -- Nationally representative cross-sectional surveys with both an inperson interview and a medical examination that included the measurement of blood lipid levels. Setting/Participants. Between 6000 and 13000 adults aged 20 through 74 years examined in each of four separate national surveys during 1960 through 1962, 1971 through 1974, 1976 through 1980, and 1988 through 1991. Results. -- Mean serum total cholesterol levels in US adults aged 20 through 74 years have consistently declined over the time period 1960 through 1991. More than half of the decline occurred during the time period 1976 through 1991. This decline occurred across the entire distribution of serum cholesterol levels and in all age-sex groups. High-density lipoprotein cholesterol and very low-density lipoprotein cholesterol levels have not changed, suggesting that the decline in total cholesterol levels is due to a decline in low-density lipoprotein cholesterol levels. Conclusions. -- These results documents a continuing and substantial decline in serum cholesterol levels among US adults. They suggest that public health programs, designed to reduce cholesterol levels, are proving successful. The observed downward trend in serum cholesterol levels has coincided with a continuing declined in coronary heart disease mortality. These observations suggest that the Healthy People 2000 goal of reducing the mean serum cholesterol level of US adults to no more than 200 mg/dL (5.17 mmol/L) is attainable. JAMA. 1993;269:3002-3008)