학술논문
Ligneous Periodontitis Associated with Plasminogen Deficiency: A Review of the Literature with Two Additional Cases
Document Type
Academic Journal
Source
Cyprus Journal of Medical Sciences. December 2022, Vol. 7 Issue 6, p718, 13 p.
Subject
Language
English
ISSN
2149-7893
Abstract
INTRODUCTION Plasminogen is a proenzyme which is converted into active plasmin by plasminogen activators on the fibrin surface. Plasminogen plays an important role in many events, such as cell migration, [...]
BACKGROUND/AIMS: Ligneous lesions are rare diseases characterized by fibrin deposition due to plasminogen deficiency and they may affect the mucosal areas as conjunctivae and gingiva. The course of this disease is progressive and typically results in early tooth loss. In this study, we aimed to evaluate the demographic, clinical, and histopathological features and treatment approaches for ligneous periodontitis lesions in the literature with additional cases of our own. MATERIALS AND METHODS: Two patients, siblings, were referred to our clinic with nodular and fragile gingival overgrowth on both jaws. Brown-yellow gingival growths which were prone to bleeding and covered the teeth were observed. While one of the siblings received pharmaceutical treatment, the other received surgical treatment. A literature search was performed to congregate articles using the PubMed database based the following terms: [(ligneous periodontitis) OR (ligneous)] OR [(ligneous periodontal disease)] AND [English (Language)]. Lesions which were not located on the gingiva were the exclusion criterion. RESULTS: The literature review revealed 72 cases of ligneous gingival lesions during the years 1973-2020. All lesions found were classified tables according to their characteristics, treatment approaches, recurrence rates, and follow-up periods. Ligneous lesions are rare diseases characterized by fibrin deposition due to plasminogen deficiency and they may affect the mucosal areas. CONCLUSION: It has been reported that there is still no consensus on treatment for these lesions. More studies are needed in the future in order to provide effective periodontal treatment for cases of ligneous periodontitis. Keywords: Ligneous periodontitis, ligneous gingivitis, plasminogen deficiency, treatment
BACKGROUND/AIMS: Ligneous lesions are rare diseases characterized by fibrin deposition due to plasminogen deficiency and they may affect the mucosal areas as conjunctivae and gingiva. The course of this disease is progressive and typically results in early tooth loss. In this study, we aimed to evaluate the demographic, clinical, and histopathological features and treatment approaches for ligneous periodontitis lesions in the literature with additional cases of our own. MATERIALS AND METHODS: Two patients, siblings, were referred to our clinic with nodular and fragile gingival overgrowth on both jaws. Brown-yellow gingival growths which were prone to bleeding and covered the teeth were observed. While one of the siblings received pharmaceutical treatment, the other received surgical treatment. A literature search was performed to congregate articles using the PubMed database based the following terms: [(ligneous periodontitis) OR (ligneous)] OR [(ligneous periodontal disease)] AND [English (Language)]. Lesions which were not located on the gingiva were the exclusion criterion. RESULTS: The literature review revealed 72 cases of ligneous gingival lesions during the years 1973-2020. All lesions found were classified tables according to their characteristics, treatment approaches, recurrence rates, and follow-up periods. Ligneous lesions are rare diseases characterized by fibrin deposition due to plasminogen deficiency and they may affect the mucosal areas. CONCLUSION: It has been reported that there is still no consensus on treatment for these lesions. More studies are needed in the future in order to provide effective periodontal treatment for cases of ligneous periodontitis. Keywords: Ligneous periodontitis, ligneous gingivitis, plasminogen deficiency, treatment