부산대학교 도서관

Natural regulatory T (Treg) cells interfere with multiple functions, which are crucial for the development of strong anti-tumour responses. In a model of 4T1 mammary carcinoma, depletion of CD25.sup.+ Tregs results in tumour regression in Balb/c mice, but the mechanisms underlying this process are not fully understood. Here, we show that partial Treg depletion leads to the generation of a particular effector CD8 T cell subset expressing CD11c and low level of PD-1 in tumour draining lymph nodes. These cells have the capacity to migrate into the tumour, to kill DCs, and to locally regulate the anti-tumour response. These events are concordant with a substantial increase in CD11b.sup.+ resident dendritic cells (DCs) subsets in draining lymph nodes followed by CD8.sup.+ DCs. These results indicate that Treg depletion leads to tumour regression by unmasking an increase of DC subsets as a part of a program that optimizes the microenvironment by orchestrating the activation, amplification, and migration of high numbers of fully differentiated CD8.sup.+ CD11c.sup.+ PD1.sup.lo effector T cells to the tumour sites. They also indicate that a critical pattern of DC subsets correlates with the evolution of the anti-tumour response and provide a template for Treg depletion and DC-based therapy.
Author(s): Nicolas Goudin [sup.1] , Pascal Chappert [sup.2] , Jérome Mégret [sup.1] , David-Alexandre Gross [sup.2] , Benedita Rocha [sup.2] , Orly Azogui [sup.2] * Introduction Accumulating evidence, in both [...]