학술논문
Anti-NMDA Receptor Encephalitis in a Patient with Tuberous Sclerosis-Related Brain Tumor: A Case Report
N-methyl-D-aspartate
N-methyl-D-aspartate
Document Type
Clinical report
Source
Case Reports in Neurology. September 2021, Vol. 13 Issue 3, p656, 8 p.
Subject
Language
English
Abstract
Author(s): Thomas Ihl [a]; Friederike A. Arlt [a]; Marie-Luise Machule [a]; Harald Prüss [a,b]; Heinrich J. Audebert [a,c] Introduction Anti-NMDA receptor (NMDAR) encephalitis (NMDARE) is an autoimmune disorder caused by [...]
Anti-NMDA receptor (NMDAR) encephalitis (NMDARE) is an important treatable cause of autoimmune psychosis in all age-groups, which is sometimes associated with tumors, especially ovarian teratomas. Tuberous sclerosis complex (TSC) is an autosomal dominant inherited neurocutaneous disease predisposing for development of benign tumors. We present a case of a 35-year-old woman with recurrent episodes of schizophrenia-like symptoms. Accidentally, MRI revealed TSC-related brain tumors. NMDAR antibody titers were strongly positive in serum and cerebrospinal fluid. This is the first case describing an overlap of NMDARE and TSC-related brain tumors. A review of brain tumors and NMDARE is given in the supplementary material. Although a causal link seems interesting from a pathophysiological point of view, we are in favor of a coincidence. Keywords: NMDA receptor encephalitis, Tuberous sclerosis complex, Primary brain tumor, Case report
Anti-NMDA receptor (NMDAR) encephalitis (NMDARE) is an important treatable cause of autoimmune psychosis in all age-groups, which is sometimes associated with tumors, especially ovarian teratomas. Tuberous sclerosis complex (TSC) is an autosomal dominant inherited neurocutaneous disease predisposing for development of benign tumors. We present a case of a 35-year-old woman with recurrent episodes of schizophrenia-like symptoms. Accidentally, MRI revealed TSC-related brain tumors. NMDAR antibody titers were strongly positive in serum and cerebrospinal fluid. This is the first case describing an overlap of NMDARE and TSC-related brain tumors. A review of brain tumors and NMDARE is given in the supplementary material. Although a causal link seems interesting from a pathophysiological point of view, we are in favor of a coincidence. Keywords: NMDA receptor encephalitis, Tuberous sclerosis complex, Primary brain tumor, Case report