학술논문
Stage-dependent changes in membrane currents in rats with monocrotaline-induced right ventricular hypertrophy
Document Type
Academic Journal
Source
The American Journal of Physiology. June, 1997, Vol. 272 Issue 6, pH2833, 10 p.
Subject
Language
ISSN
0002-9513
Abstract
Whole cell patch-clamp techniques were utilized to examine changes in the ventricular action potential configuration of rats during monocrotaline (MCT)-induced right ventricular (RV) hypertrophy. Myocardial hypertrophy secondary to pressure overload induced complex stage-dependent changes in the ionic currents of ventricular cells from rat with MCT-induced hypertrophy. The stage-dependent changes in the macroscopic membrane currents of hypertrophied ventricular cells were also induced by RV pressure overload.