학술논문
Effects of a 5-lipoxygenase-activating protein inhibitor on biomarkers associated with risk of myocardial infarction: A randomized trial
Document Type
Academic Journal
Author
Hakonarson, Hakon; Andresdottir, Margret; Zink, Florian; Gudbjartsson, Daniel; Helgadottir, Anna; Thorvaldsson, Sverrir; Manolescu, Andrei; Jonsson, Asgeir; Thorgeirsson, Gestur; Sigurdsson, Axel; Andersen, Karl; Arnar, David O.; Agnarsson, Uggi; Adalsteinsdottir, Asdis E.; Gudmundsdottir, Hrefna; Einarsson, Atli; Gottskalksson, Gizur; Bjornsdottir, Halldora; Gudmundsson, Kolbeinn; Gulcher, Jeffrey; Topol, Eric J.; Kristinsson, Arni; Hardarson, Thordur; Kristjansson, Kristleifur; Kong, Augustine; Stefansson, Kari; Thorgeirssonj, Gudmundur; Gurney Mark
Source
JAMA, The Journal of the American Medical Association. May 11, 2005, Vol. 293 Issue 18, p2245, 12 p.
Subject
Language
English
ISSN
0098-7484
Abstract
A study is conducted to determine the effect of an inhibitor of 5-lipoxygenase-activating protein (FLAP) on levels of biomarkers associated with myocardial infarction (MI) risk. It is concluded that in patients with specific at-risk variants of 2 genes in the leukotriene pathway, DG-031 led to significant and dose-dependent suppression of biomarkers that are associated with increased risk of MI events.