부산대학교 도서관

Introduction: Justicia schimperiana has been used traditionally for the treatment of wound and skin bum, but there is no scientific evidence that supports the traditional claim. Objective: To evaluate the wound healing activity of 80% methanol crude extract and solvent fractions of the leaves of Justicia schimperiana in mice. Methods: Mice were used for wound healing study, while rats were used for acute dermal toxicity test. The 80% methanol crude extract and chloroform, ethyl acetate and aqueous fractions were formulated in ointments with 5% and 10% strength. Burn, excision and incision wound models were used to evaluate the effect of the crude extract, whereas the activity of the solvent fractions was evaluated using excision wound model. Parameters such as wound contraction, and period of epithelialization were studied in the excision and burn wound models, while tensile strength was measured in incision wound model. Results: Treatment of wound with 80% methanol extract of Justicia schimperiana leaves using 5% (w/w) and 10% (w/w) ointment formulation induced significant (P Conclusion: This study has demonstrated that the 80% methanol crude extract and solvent fractions of Justicia schimperiana leaves possess wound healing activity. Keywords: Justicia schimperiana, wound, wound healing
Introduction Wounds are significant causes of morbidity and mortality worldwide. Studies showed that there are 10,000 deaths due to microbial infections for every million wound patients. (1,2) Chronic wounds have [...]