부산대학교 도서관

New antithrombotic drug GRS, a soluble guanylate cyclase stimulator, after repeated administration in a dose of 10 mg/kg alleviates the symptoms of endothelial dysfunction in rats with myocardial infarction; it restores antiplatelet activity of the blood vessel wall and vasodilatory function of the endothelium without producing significant effect on endothelium-independent vasodilation. GRS also has direct antiaggregant and antihypertensive effects in therapeutic doses. The obtained data suggest that GRS can be therapeutically useful in patients with cardiovascular diseases accompanied by endothelial dysfunction. Key Words: soluble guanylate cyclase stimulator GRS; endothelial dysfunction; myocardial infarction
Endothelial dysfunction is an important factor in the pathogenesis of many cardiovascular diseases, including atherosclerosis, coronary heart disease (CHD) and arterial hypertension [3,6,9] and represents a persistent pathological change in [...]