부산대학교 도서관

To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.cardiores.2006.12.010 Byline: Mohammad Shakil Ahmed (a)(c), Erik Aie (a)(b), Leif Erik Vinge (a)(c), Thomas G. von Lueder (a)(c), Toril Attramadal (a), HA[yen]vard Attramadal (a)(b)(c) Keywords: Heart failure; Growth factor; Remodeling; Macrophages; Pulmonary circulation Abstract: Pulmonary remodeling is a well recognized consequence of heart failure (HF). However, the cellular and molecular mechanisms orchestrating the structural alterations of the lungs in HF are poorly understood. We have previously reported induction of the profibrotic peptide connective tissue growth factor (CTGF) in myocardial tissue of rats with HF, suggesting a role of CTGF during myocardial remodeling. The aim of the present study was to explore the potential role of CTGF in pulmonary remodeling in HF. Author Affiliation: (a) Institute for Surgical Research, University of Oslo, N-0027 Oslo, Norway (b) Department of Cardiology, Rikshospitalet University Hospital, Sognsvannsveien 20, N-0027 Oslo, Norway (c) Faculty Division Rikshospitalet, University of Oslo, N-0027 Oslo, Norway Article History: Received 24 May 2006; Revised 7 December 2006; Accepted 11 December 2006 Article Note: (miscellaneous) Time for primary review 28 days