학술논문
Circulating E-selectin and tumor necrosis factor-[alpha] in extraarticular involvement and joint disease activity in rheumatoid arthritis
Document Type
Report
Author
Source
Rheumatology International. Jan, 2009, Vol. 29 Issue 3, p281, 6 p.
Subject
Language
English
ISSN
0172-8172
Abstract
In this cross-sectional study, we assessed the relationship between circulating TNF-[alpha] and E-selectin (sE-selectin) with extraarticular involvement and severity of joint disease in RA. We compared 56 patients who had RA and extraarticular involvement (ExRA) with a group of 84 patients with only articular involvement (non-ExRA). ExRA had higher circulating TNF-[alpha] than non-ExRA (32 +- 9 vs. 28 +- 6 pg/mL, P = 0.002). sE-selectin levels did not differ between both groups. sE-selectin correlated with tender joint count (rho = 0.19, P = 0.03), morning stiffness (rho = 0.19, P = 0.03), severity of pain (rho = 0.21, P = 0.02), disease activity (assessed by the patient) (rho = 0.21, P = 0.02), HAQ-DI (rho = 0.29, P = 0.004), and rheumatoid factor titers (rho = 0.31, P =