부산대학교 도서관

Lassa fever is endemic in West Africa, with an estimated 300,000 to 500,000 infections occurring annually and approximately 5,000 deaths. Two Lassa fever cases in pregnancy with maternal and fetal complications were presented. The age range was 20 to 30 years and the range of parity was 1 to 3. The duration of symptoms was 13 to 14days. Clinical presentation and complications common to the two cases were fever, abnormal bleeding, cough/sore throat, anaemia, IUFD/Stillbirth, and maternal deaths. Others are vomiting, restlessness/confusion, hypotension and thrombocytopaenia. Major challenges encountered are late presentation, delay in confirming diagnosis and instituting definitive treatment, limited facility, and the impact of traditional and religious factors in safe burial for Lassa fever cases. In resource-constrained settings; diagnosis, treatment and surveillance for Lassa fever may be challenging. Early clinical suspicion and appropriate case management are critical for good reproductive outcome. (Afr J Reprod Health 2022; 26[2]: 137-143). Keywords: Lassa fever, haemorrhagic fever, infection prevention, pregnancy outcome La fievre de Lassa est endemique en Afrique de l'Ouest, avec environ 300 000 a 500 000 infections par an et environ 5 000 deces. Deux cas de fievre de Lassa au cours d'une grossesse avec complications maternelles et foetales ont ete presentes. La tranche d'age etait de 20 a 30 ans en moyenne et la tranche de parite etait de 1 a 3. La duree des symptomes etait de 13 a 14 jours. La presentation clinique et les complications communes aux deux cas etaient la fievre, les saignements anormaux, la toux/le mal de gorge, l'anemie, le DIU/la mortinaissance et les deces maternels. D'autres sont les vomissements, l'agitation/la confusion, l'hypotension et la thrombocytopenie. Les principaux defis rencontres sont la presentation tardive, le retard dans la confirmation du diagnostic et l'instauration du traitement definitif, les installations limitees et l'impact des facteurs traditionnels et religieux sur l'inhumation en toute securite des cas de fievre de Lassa. Dans des environnements a ressources limitees; le diagnostic, le traitement et la surveillance de la fievre de Lassa peuvent etre difficiles. Une suspicion clinique precoce et une prise en charge appropriee des cas sont essentielles pour un bon resultat reproductif. (Afr J Reprod Health 2022; 26[2]: 137-143). Mots-cles: Fievre de Lassa, fievre hemorragique, prevention des infections, issue de la grossesse
Introduction Lassa fever, a form of viral haemorrhagic fever caused by the Lassa virus, is endemic in West Africa (1). The virus was first identified in 1969 when two missionary [...]