학술논문

Suicides in National Hormone Pituitary Program Recipients of Cadaver-Derived Human Growth Hormone
Research Article
Document Type
Academic Journal
Source
Journal of the Endocrine Society. December 2023, Vol. 7 Issue 12
Subject
United States. National Institutes of Health
Health aspects
Mortality
Medical records -- Health aspects
Somatotropin -- Health aspects
Suicide -- Health aspects
Medical research -- Health aspects
Medicine, Experimental -- Health aspects
Language
English
ISSN
2472-1972
Abstract
In 1960, the National Institutes of Health (NIH) and the College of American Pathologists formed the National Pituitary Agency to coordinate collection and extraction of cadaver-derived human growth hormone (c-hGH) [...]
Context: Numerous reports of suicide among individuals who received cadaver-derived human growth hormone (c-hGH) through the National Hormone Pituitary Program (NHPP) raised the alarm for potentially increased suicide risk. Objective: We conducted a study to assess suicide risk in the NHPP cohort and identify contributing factors to facilitate early recognition and intervention. Methods: The study population consisted of patients receiving NHPP c-hGH starting from 1957, and cohort deaths with an ICD code consistent with suicide or possible suicide through 2020 were evaluated. Descriptive data were extracted from medical records. Standardized mortality ratios (SMRs) to compare the observed number of suicide deaths in the cohort to the expected number were calculated using general population suicide rates by sex, age group, and time period. Results: Among 6272 patients there were 1200 all-cause cohort deaths, of which 55 (52 male, 3 female) were attributed to suicide. Of these, 47 were identified by ICD code alone compared to an expected count of 37.8 (SMR = 1.25, 95% CI 0.91-1.66). Among male cohort members, the SMR was 1.33 (95% CI 0.97-1.78). Elevated risk of suicide was detected for cohort members aged 25-34 (SMR = 1.79, 95% CI 1.06-2.83) and during the period from September 19, 1985, to December 31, 1998 (SMR = 1.70, 95% CI 1.02-2.65). Conclusion: Overall, the observed number of suicides among NHPP c-hGH recipients was not significantly higher than expected. However, certain subgroups may be at elevated risk of suicide. Studies are needed to better understand the nature and magnitude of suicide risk among c-hGH recipients to facilitate early intervention to prevent suicide deaths. Key Words: human growth hormone, pituitary growth hormone, suicide, US cohort study, short stature