부산대학교 도서관

Background: Complete blood count parameters provide novel inflammatory markers, namely neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR). We aimed to assess any differences in these novel inflammatory markers according to exacerbation severity in patients with COPD in both eosinophilic and neutrophilic endotypes. Method: This retrospective cross-sectional study was conducted at a tertiary education hospital. Previously diagnosed COPD patients admitted to the hospital with acute COPD exacerbation (AECOPD) were enrolled into the study. Patients were grouped according to COPD endo-type, eosinophilic (peripheral blood eosinophil rate [greater than or equal to]2%) and neutrophilic (peripheral blood eosinophil rate Results: Of the 10,592 patients included in the study, 7,864 were admitted as outpatients, 2,233 to the wards, and 495 to ICU. Neutrophilic COPD patients (n=6,536, 62%) had increased inflammatory markers compared with eosinophilic COPD patients (n=4,056, 38%); median NLR was 5.11 vs 2.62 (P Conclusion: In COPD exacerbation, the inflammatory markers show different increases in each COPD endotypes. These findings may be crucial for defining exacerbation endotypes, the severity of exacerbation, and treatment response during follow-up in COPD patients. Keywords: outpatients, inflammatory biomarkers, COPD attack, ward and intensive care, hospitalization
Introduction COPD exacerbation requiring hospitalization is one of the most important causes of morbidity and mortality. (1) When acute respiratory failure occurs due to acute exacerbation of COPD (AECOPD), and [...]