부산대학교 도서관

Epstein-Barr virus (EBV) is a widely disseminated herpesvirus for which antibodies have been demonstrated in over 90% of adults worldwide. After subclinical primary EBV infections, as well as after infectious mononucleosis, the virus can be shed in saliva for a prolonged period of time. Aim: Diseases and disorders that can induce EBV salivary shedding include mental disorders and sex, connective tissue disease, multiple sclerosis, systemic lupus erythematosus, malaria and HIV infection. Since the occurrence of EBV in saliva during acute infectious diseases has not yet been systematically researched, we aimed to investigate the possible relationship between acute infectious diseases and salivary shedding of EBV. Material and methods: This pilot cross-sectional study included consenting adults hospitalized for acute infectious conditions and their peers free of acute infectious diseases. A total of 40 patients with acute infectious diseases were enrolled, along with 41 adults free of acute infections. Peripheral venous blood samples for serodiagnosis and saliva samples for EBV PCR testing were collected from both groups. We fitted logit and general linear models to proportions and to ln (viral copy counts) to generate adjusted proportions and geometric mean values in the two groups of subjects. We used SAS for Windows 9.4. Results: The most common acute infectious disease was COVID-19 pneumonia, followed by hemorrhagic fever with renal syndrome. Crude proportions of people with positive serological test results and those with saliva viral shedding were similar in the two groups. Conclusions: The presented preliminary data do not indicate acute infectious conditions as a marked 'contributor' in increasing salivary EBV shedding. Epstein-Barrov virus (EBV) siroko je rasprostranjen herpesvirus pa 90 % odrasle svjetske populacije ima protutijela. Nakon supklinickih primarnih infekcija EBV-om i poslije infektivne mononukleoze, virus se moze dulje izlucivati u slini. Bolesti i stanja koja se pritom pojavljuju obuhvacaju mentalne poremecaje, bolesti vezivnoga tkiva, multiplu sklerozu, sistemski eritemski lupus, malariju i infekciju HIV-om. Cilj: Kako pojava EBV-a u slini tijekom akutnih infektivnih bolesti do sada nije sustavno istrazena, cilj je bio istraziti mogucu vezu izmedu akutnih zaraznih bolesti i izlucivanja EBV-a u slini. Materijal i metode: U ovo presjecno pilot-istrazivanje ukljuceni su odraslih bolesnici hospitalizirani zbog akutnih infektivnih bolesti te kontrolna skupina s osobama bez akutnih zaraznih bolesti. Odabrano je ukupno 40 bolesnika s akutnim infektivnim bolestima i kao kontrola 41 zdrava osoba. Od ispitanika iz obje skupine uzeti su uzorci periferne venske krvi za serodijagnostiku i uzorci sline za EBV PCR testiranje. Prilagodeni su logit i opci linearni modeli prema proporcijama te ln (broj virusnih kopija) u svrhu generiranja prilagodenih proporcija i geometrijskih srednjih vrijednosti u dvjema skupinama ispitanika. Upotrijebljen je SAS za Windows 9.4. Rezultati: Najcesca akutna infektivna bolest bila je pneumonija COVID-19, a slijedi hemoragijska vrucica s bubreznim sindromom. Proporcije ispitanika s pozitivnim seroloskim testovima i onih s izlucivanjem virusa u slini bile su slicne u objema skupinama. Zakljucak: Nasi preliminarni rezultati pokazuju da akutne infektivne bolesti ne utjecu bitno na pojavu EBV kopija u slini.
Introduction: Epstein-Barr virus (EBV) is a widely disseminated herpesvirus that is spread by intimate contact between asymptomatic EBV shedders and susceptible persons. Antibodies to EBV have been demonstrated in over [...]