학술논문
TRANSIENT BENIGN HYPERPHOSPHATASEMIA DUE TO ROTAVIRUS GASTROENTERITIS/ROTAVIRUS GASTROENTERITINE BAGLI GECICI BENIGN HIPERFOSFATAZEMI
CASE REPORT / OLGU SUNUMU
CASE REPORT / OLGU SUNUMU
Document Type
Clinical report
Source
Journal of Istanbul Faculty of Medicine. December 2023, Vol. 86 Issue 4, p402, 4 p.
Subject
Language
English
ISSN
1305-6433
Abstract
INTRODUCTION Alkaline phosphatase (ALP) is present in different concentrations in many tissues such as the placenta, ileal mucosa, kidney, bone, and liver. In healthy individuals, more than 80% of ALP [...]
Transient benign hyperphosphatasemia (TBH) is a benign condition characterized by transiently elevated serum alkaline phosphatase (ALP) levels by 3-50 times normal values. It can sometimes be seen in connection with different clinical disorders such as respiratory tract infections, gastrointestinal diseases, congenital metabolic disorders, malignancies, congenital anomalies, anemia, and neurological disorders. In this report, we describe three children who had TBH after rotavirus-associated gastroenteritis and in whom there was no evidence of liver or bone disease. We aim to raise awareness and draw attention to TBH in this case report. Keywords: Transient hyperphosphatasemia, alkaline phosphatase, rotavirus, gastroenteritis, children Gecici benign hiperfosfatazemi (TBH), serum alkalen fosfataz (ALP) duzeylerinin normalin 3-50 kati kadar gecici olarak yuk- selmesi ile karakterize ve bazen de gastrointestinal hastaliklar, solunum yolu enfeksiyonlari, dogumsal anomaliler, dogumsal metabolik bozukluklar, anemi, maligniteler, norolojik bozukluk- lar gibi farkli klinik bozukluklarla birlikte gorulebilmektedir. Bu calismada, karaciger veya kemik hastaligi olmayan, rotavirus ile iliskili gastroenterit sonrasi TBH'li uc cocuk sunuldu. Bu olgularin sunulmasi ile TBH konusuna dikkat cekilmesi ve farkindalik yara- tilmasi amaclandi. Anahtar Kelimeler: Gecici hiperfosfatazemi, alkalin fosfataz, ro- tavirus, gastroenterit, cocukluk evresi
Transient benign hyperphosphatasemia (TBH) is a benign condition characterized by transiently elevated serum alkaline phosphatase (ALP) levels by 3-50 times normal values. It can sometimes be seen in connection with different clinical disorders such as respiratory tract infections, gastrointestinal diseases, congenital metabolic disorders, malignancies, congenital anomalies, anemia, and neurological disorders. In this report, we describe three children who had TBH after rotavirus-associated gastroenteritis and in whom there was no evidence of liver or bone disease. We aim to raise awareness and draw attention to TBH in this case report. Keywords: Transient hyperphosphatasemia, alkaline phosphatase, rotavirus, gastroenteritis, children Gecici benign hiperfosfatazemi (TBH), serum alkalen fosfataz (ALP) duzeylerinin normalin 3-50 kati kadar gecici olarak yuk- selmesi ile karakterize ve bazen de gastrointestinal hastaliklar, solunum yolu enfeksiyonlari, dogumsal anomaliler, dogumsal metabolik bozukluklar, anemi, maligniteler, norolojik bozukluk- lar gibi farkli klinik bozukluklarla birlikte gorulebilmektedir. Bu calismada, karaciger veya kemik hastaligi olmayan, rotavirus ile iliskili gastroenterit sonrasi TBH'li uc cocuk sunuldu. Bu olgularin sunulmasi ile TBH konusuna dikkat cekilmesi ve farkindalik yara- tilmasi amaclandi. Anahtar Kelimeler: Gecici hiperfosfatazemi, alkalin fosfataz, ro- tavirus, gastroenterit, cocukluk evresi