부산대학교 도서관

Changes in the proteasome chymotrypsin-like activity in mammary and thyroid carcinomas in comparison with the adjacent tissue were studied at stages [T.sub.1-4][N.sub.0-3][M.sub.0] and [T.sub.2-3][N.sub.0- 1][M.sub.0], respectively. The activities changed in a wave-like manner over the course of mammary carcinoma growth in cases with and without metastases. The minimum increment of the activity in the tumor was recorded during the [T.sub.2][N.sub.0] stage in the absence of local metastases. The increment of the activity reached the peak in [N.sub.1] tumors of the same size with metastases. The activities in the tumor and adjacent tissues virtually did not differ during the [T.sub.3-4][N.sub.1-3] stages. The time course of proteasome activity changes in thyroid tumors of the studied stages was similar to that in mammary carcinoma. The results can be used for development of methods for evaluating the aggressiveness of mammary and thyroid tumors. Key Words: mammary and thyroid carcinomas; metastases; proteasomes; proteasome chymotrypsin-like activity
Detection of the molecular mechanisms of malignant tumor development remains one of the most important problems of biology and medicine. Solution of this problem will make us closer to understanding [...]