학술논문
Brain Tumors and the Lynch Syndrome
Document Type
TEXT
Author
Source
Subject
Language
English
Abstract
Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposiscolorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused bygermline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the mostprevalent cancer syndromes in man and is estimated to account for 1-6% of all colorectalcancers (Lynch & de la Chapelle, 2003).